By Wayne Mutza
C7 Caribou in motion
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Additional resources for C-7 Caribou in action No 132
15 Mouse Chr. 10 SCRT1 DGAT1 HSF1 BOP1 HSF2 SERINC1 HSF2 SERINC1 Human Chr. 6 Human Chr. 8 SCRT1 HSF1 BOP1 DGAT1 HSF2 10 kb SERINC1 HSF3 HSF4 Chicken Chr. 4 10 kb Vsig4 Mouse Chr. X Vsig4 HSF3 HSF3 Chicken Chr. 11 TRADD HEPH 100 kb Mouse Chr. 8 HEPH TRADD HSF4 NoL3 FBXL8 100 kb HSF3 HSF4 FBXL8 HEPH Human Chr. X Vsig4 20 kb Human Chr. 16 TRADD FBXL8 HSF4 10 kb NoL3 Fig. 6 Syntenic regions containing the vertebrate HSF genes. The location of each segment is as follows: HSF1, human Chr. 3 and mouse Chr.
In contrast to the strong potential of mammalian HSF1 to activate transcription upon heat shock, the potential of HSF2 and HSF4 is weak in both unstressed and heat-shocked conditions (Tanabe et al. 1999; Yoshima et al. 1998a) (Fig. 5b). Nevertheless, HSF2 and HSF4 have a potential to activate the reporter gene constitutively, and HSF4 induces the gene expression in response to proteotoxic stresses including heat shock. a. a. a. a. a. 428–445) are present (Yoshima et al. 1998b). a. a. 200–295) (Nakai et al.
In plants, 252 HSF family members, which have similar structures and 2 Structure and Function of the HSF Family Members a 41 b 500 450 400 350 300 250 200 150 100 50 lamprey coelacanth Fish shark frog Amphibian andrias turtle snake lizard Reptile 440 Myr 2R WGD dipnoi bird Avian alligator Mammal placentalia Shark 1 2 3 Coelacanth 1 2 x 4 Medaka 1 2 x 4 Zebra Fish 1 2 x 4 Frog 1 2 3 4 Turtle 1 2 3 4 Lizard 1 2 3 4 Alligator 1 2 3 4 Chicken 1 2 3 4 Zebra Finch 1 2 3 4 Rat 1 2 3 4 Mouse 1 2 3 4 Chimpanzee 1 2 x 4 Human 1 2 3 4 Fish HSF1, 2, 4 Amphibia HSF1, 2 Reptile HSF1, 2, 3, 4 Avian HSF1, 2, 3, 4 Mammal monotremes marsupialia Cloned gene or cDNA HSF gene Myr 3 4 HSF1, 2, 4 pseudogene Fig.