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By P. Kochhar

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1-2, pp. 237-255. , & Yamamoto, F. (1997). Evolution of primate ABO blood group genes and their homologous genes. Molecular Biology and Evolution, Vol. 14, No. 4, 399-411. , Michaels, M. , Tilley, C. , Crookston, M. , & Crookston, J. H. (1973). Qualitative differences in the N-acetyl-D-galactosaminyltransferases produced by human A1 and A2 genes. Proceedings of the National Academy of Sciences U S A, Vol. 70, No. 1, pp. 220-224. ISSN 0027-8424 Shaper, N. , Lin, S. , Joziasse, D. , Kim, D. , & Yang-Feng, T.

New York, USA Kelly, R. , Lennon, G. , & Lowe, J. B. (1995). Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype. Journal of Biological Chemistry, Vol. 270, No. 9, pp. 4640-4649. ISSN 0021-9258 Keusch, J. , Manzella, S. , Nyame, K. , Cummings, R. , & Baenziger, J. U. (2000). Expression cloning of a new member of the ABO blood group glycosyltransferases, iGb3 synthase, that directs the synthesis of isoglobo-glycosphingolipids.

Consequently, many who are undergoing major orthopaedic surgery will be at high risk of cardiovascular complications (Neill 2000). The incidence of anaemia increases with age (Ania 1997) and is four to six times greater than can be predicted by clinical symptoms in the over 65 year age group (Ania 1997). Perioperative anaemia in the elderly is not without morbidity and includes fatigue, tachycardia, hypotension, dyspnoea and impaired level of consciousness (Spence 1998) and can be associated with decreased vigour, potentially prolonging the duration of hospital stay (Bierbaum 1999;Keating 1999) and affecting quality of life.

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