By Dennis E Vance
Study at the biochemistry and molecular biology of lipids and lipoproteins has skilled amazing development within the final two decades, relatively with the belief that many alternative sessions of lipids play primary roles in illnesses comparable to middle affliction, weight problems, diabetes, melanoma and neurodegenerative problems. The fifth version of this e-book has been written with significant goals. the 1st aim is to supply scholars and academics with a complicated up to date textbook protecting the foremost parts of present curiosity within the lipid box. The chapters are written for college kids and researchers acquainted with the overall thoughts of lipid metabolism yet who desire to extend their wisdom during this region. the second one target is to supply a reference textual content for scientists who're approximately to go into the sphere of lipids, lipoproteins and membranes and who desire to study extra approximately this zone of analysis. the entire chapters were broadly up-to-date because the 4th version seemed in 2002. Key positive factors: * Represents a bridge among the superficial insurance of the lipid box present in simple biochemistry textual content books and the hugely really expert fabric contained in clinical evaluate articles and monographs. * permits scientists to get to grips with fresh advancements relating to their very own examine pursuits, and should support medical researchers and clinical scholars hold abreast of advancements in simple technological know-how which are vital for next medical advances. * Serves as a normal reference booklet for scientists learning lipids, lipoproteins and membranes and as a complicated and updated textbook for academics and scholars who're conversant in the elemental strategies of lipid biochemistry learn more... content material: useful roles of lipids in membranes / William Dowhan, Mikhail Bogdanov, and Eugenia Mileykovskaya -- Lipid variations of proteins / Anant okay. Menon -- Fatty acid and phospholipid metabolism in prokaryotes / Charles O. Rock -- Lipid metabolism in crops / Katherine M. Schmid and John B. Ohlrogge -- Oxidation of fatty acids in eukaryotes / Horst Schulz -- Fatty acid synthesis in eukaryotes / Hei Sook Sul and Stuart Smith -- Fatty acid desaturation and chain elongation in mammals / Makoto Miyazaki and James M. Ntambi -- Phospholipid biosynthesis in eukaryotes / Dennis E. Vance and Jean E. Vance -- Ether-linked lipids and their bioactive species / Thomas M. McIntyre, Fred Snyder, and Gopal ok. Marathe -- Lipid metabolism in adipose tissue / Ann V. Hertzel ... [et al.] -- Phospholipases / David C. Wilton -- The eicosanoids : cyclooxygenase, lipoxygenase, and epoxygenase pathways / William L. Smith and Robert C. Murphy -- Sphingolipids / Alfred H. Merrill, Jr. -- ldl cholesterol biosynthesis / Laura Liscum -- Metabolism and serve as of bile acids / Luis B. Agellon -- Lipid meeting into mobilephone membranes / Dennis R. Voelker -- Lipoprotein constitution / Ana Jonas and Michael C. Phillips -- meeting and secretion of triacylglycerol-rich lipoproteins / Jean E. Vance and Khosrow Adeli -- Dynamics of lipoprotein shipping within the circulatory method / Christopher J. Fielding and Phoebe E. Fielding -- Lipoprotein receptors / Wolfgang J. Schneider -- Lipids and atherosclerosis / Ira Tabas. summary: examine at the biochemistry and molecular biology of lipids and lipoproteins has skilled outstanding progress within the final two decades, relatively with the belief that many various sessions of lipids play primary roles in ailments akin to center illness, weight problems, diabetes, melanoma and neurodegenerative problems. The fifth variation of this booklet has been written with significant pursuits. the 1st goal is to supply scholars and lecturers with a complicated up to date textbook masking the main components of present curiosity within the lipid box. The chapters are written for college kids and researchers conversant in the overall recommendations of lipid metabolism yet who desire to extend their wisdom during this zone. the second one aim is to supply a reference textual content for scientists who're approximately to go into the sector of lipids, lipoproteins and membranes and who desire to examine extra approximately this region of analysis. the entire chapters were broadly up to date because the 4th variation seemed in 2002. Key good points: * Represents a bridge among the superficial assurance of the lipid box present in easy biochemistry textual content books and the hugely really good fabric contained in medical evaluate articles and monographs. * permits scientists to get to grips with contemporary advancements regarding their very own learn pursuits, and may support scientific researchers and clinical scholars preserve abreast of advancements in uncomplicated technological know-how which are vital for next scientific advances. * Serves as a basic reference publication for scientists learning lipids, lipoproteins and membranes and as a complicated and up to date textbook for lecturers and scholars who're acquainted with the elemental techniques of lipid biochemistry
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Extra resources for Biochemistry of lipids, lipoproteins and membranes : (5th edn.)
Anionic phospholipids have a particularly important function in energy-transducing membranes such as the bacterial cytoplasmic membrane and the inner mitochondrial membrane. In particular, CL has been shown to be a key factor in the maintenance of the optimal activity of the major integral proteins of the inner mitochondrial membrane, including NADH dehydrogenase, the cytochrome bc1 complex, ATP synthase, cytochrome c oxidase, and the ATP/ADP translocase . CL is an integral part of the structure of E.
The only non-bilayer-forming lipid in E. coli mutants lacking PE is CL. Protein translocation into inverted membrane vesicles prepared from PE-lacking cells (now enriched in CL) is reduced with divalent cation-depletion but can be enhanced by inclusion of Mg2ϩ or Ca2ϩ . Protein translocation in the absence of divalent cations was restored by incorporation of non-bilayer PE (18:1 acyl chains) but not by bilayer-prone PE (14:0 acyl chains). These results indicate that lipids with a tendency to form non-bilayer structures provide a necessary environment for translocation of proteins across the membrane.
The liquid-ordered- to liquid-disordered-phase transition temperature of rafts is up to 15°C above the transition temperature of the surrounding lipid bilayer because of the high cholesterol and sphingomyelin content (C. Leidy, 2004). Many cell surface receptors co-localize to lipid rafts by virtue of the apparent specificity of their transmembrane domains for the raft environment (J. Bock, 2003). Also co-clustered with lipid rafts are soluble globular protein domains tethered to the raft lipids via covalent linkage to fatty acids, cholesterol, isoprenoid compounds, or PI (Chapter 2).