By J. F. Theis, C. S. Newlon (auth.), Prof. Dr. Robert Brambl, Prof. Dr. George A. Marzluf (eds.)
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Additional resources for Biochemistry and Molecular Biology
1995). The inefficient replication initiation seen in a temperature-sensitive ede6 strain is likely the result from leakiness of the mutation, because depletion of Cdc6p results in a strikingly different phenotype. In this case, both S. pombe strains depleted for edc18+ gene product (Kelly et al. 1993) and S. eerevisiae strains depleted of Cdc6p (Piatti et al. 1995) undergo a transient arrest at the GlIS boundary and then undergo an abortive mitosis in the absence of DNA synthesis, resulting in cell death.
Genetics 129:343-357 Newlon CS, Collins I, Dershowitz A, Deshpande AM, Greenfeder SA, Ong LY, Theis IF (1993) Analysis of replication origin function on chromosome III of Saccharomyces cerevisiae. Cold Spring Harbor Symp Quant BioI48:415-423 Norman C, Rusnwick M, Pollock R, Treisman R (1988) Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element. Cell 55:989-1003 Oliver SG, van der Aart QJM. Agostoni-Carbone ML, Aigle M et al.
Genetics 134:175-188 Reynolds AE, McCarroll RM, Newlon CS, Fangman WL (1989) Time of replication of ARS elements along yeast chromosome IH. Mol Cell Biol 10:44884494 Rhode PR, Sweder KS, Oegema KF, Campbell lL (1989) The gene encoding ARS-binding factor I is essential for the vi ability of yeast. Genes Dev 3:1926-1939 Rhode PR, Eisasser S, Campbell lL (1992) Role of multifunctional autonomously replicating sequence binding factor 1 in the initiation of DNA replication and transcriptional control in Saccharomyces cerevisiae.